Connexin43 as a Tumor Suppressor: Proposed Connexin43 mRNA-circularRNAs-microRNAs Axis Towards Prevention and Early Detection in Breast Cancer
نویسندگان
چکیده
منابع مشابه
Prohibitin 2 mRNA downregulation in breast cancer tumor tissues
Introduction: Breast cancer is the most important cause of cancer mortality among women, therefore the study of its causative or aggravating factors seems necessary. In this study, the mRNA levels of the PHB2 gene were evaluated in tumor and adjacent non-tumor tissues of 50 women diagnosed with invasive ductal carcinoma of the breast. Methods: RNX-Plus solution was used to isolate total RNA fro...
متن کاملConnexin43 Hemichannel-Mediated Regulation of Connexin43
BACKGROUND Many signaling molecules and pathways that regulate gap junctions (GJs) protein expression and function are, in fact, also controlled by GJs. We, therefore, speculated an existence of the GJ channel-mediated self-regulation of GJs. Using a cell culture model in which nonjunctional connexin43 (Cx43) hemichannels were activated by cadmium (Cd(2+)), we tested this hypothesis. PRINCIPA...
متن کاملAltered expression of connexin43 and phosphorylation connexin43 in glioma tumors.
In this study, we aim to evaluate the connexin (Cx43) and phosphorylation Cx43 (p-Cx43) expression of human glioma tumors and correlate their expression with degrees of malignancy and proliferation, apoptosis, and migration activity of tumors. Cx43 and p-Cx43 expression were examined by Western blot analysis and immunohistochemical staining. The U251 cell viability was measured by MTT analysis....
متن کاملEarly Detection of Breast Cancer among Women in Mazandaran, Iran
Background and purpose: After lung cancer, breast cancer, among the prevalent cancers of the world is of the most widespread disease among women. It is the most common cause of mortality among women. This study aimed to analyze the results using breast cancer screening methods among women over 20 years old. Materials and methods: The present study is a cross-sectional-descriptive research. The ...
متن کاملConnexin43 and ischemic preconditioning.
Connexin43 (Cx43) is the essential protein to form hemichannels and gap junctions in the myocardium. The phosphorylation status of Cx43 which is regulated by a variety of protein kinases and phosphatases determines hemichannel and/or gap junction conductance and permeability. Gap junctions are involved in cell-cell coupling while hemichannels contribute to cardiomyocyte volume regulation. Cx43-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Medicine
سال: 2019
ISSN: 2296-858X
DOI: 10.3389/fmed.2019.00192